In a 2010 interview, Hurt explained that she never felt comfortable playing the lead, preferring the responsibility of supporting roles. According to Hurt, supporting characters offered more opportunities to explore the idiosyncrasies and complexities of the characters. Born on September 26, 1946, in Iowa, Mary Beth Supinger, the daughter of a Marine lieutenant and a mother who took her to the theater, had a childhood marked by art.
Before her success, Jean Seberg, another future actress, was her babysitter. After graduating from high school, she studied drama at the University of Iowa and then at NYU's Tisch School of the Arts, where she met and married William Hurt. Her career took her to London, where she performed with the theater company The Questors.