Jorge Martin delivered a stunning performance to secure victory in the US MotoGP Sprint on the final lap, overtaking rival Francesco Bagnaia. Martin gambled on the medium rear tire before the race began and fully utilized its longevity, moving from seventh on the grid to fourth by the end of the first lap. The race was filled with drama from the start, with incidents shaping the pace and strategy of the riders. Martin's boldness in tire selection and his skill on the track were key to his triumph. His ability to maintain tire performance throughout the race was crucial.

Bagnaia, starting from the second row, had a strong start and took the lead ahead of KTM's Pedro Acosta, who finished second. Marquez also got off to a good start, moving from sixth to third in the first corner. However, a firm move by pole-sitter Di Giannantonio relegated the Spaniard to fourth place in Turn 3. On the final lap, Martin cut almost a second off the Italian's lead to make it a tense final shoot-out. At Turn 12, the Spaniard made his move, forcing Bagnaia wide and taking the lead of the race.

Marquez tried to regain the position on the run to Turn 12, but braked far too late and crashed out of the corner, taking Di Giannantonio with him and ending their chances of victory. After overtaking Pedro Acosta and Joan Mir, Martin found himself behind teammate Marco Bezzecchi, until the latter crashed with three laps to go. Despite the crash, Martin managed to close the gap on Bagnaia and deliver an unforgettable race finish.

Acosta crossed the line in third place but was immediately placed under investigation for tire pressures. Enea Bastianini used his traditional late-race pace to move up to fourth, overtaking Alex Marquez, who settled for fifth on the final lap. Luca Marini took the flag in sixth ahead of the Trackhouse Aprilia pair, with Raul Fernandez in seventh and Ai Ogura in eighth. Johann Zarco earned the final point in ninth, while Fermin Aldeguer completed the top 10.

Fabio Quartararo was the top Yamaha in a distant 11th, while Brad Binder crossed the line in 12th. Franco Morbidelli struggled to 13th after spending most of the race in last place, while Jack Miller had tire problems in 14th. Mir suffered a late crash out of podium contention but rejoined in 15th, while Alex Rins also had a late-off and reclaimed 16th. Marquez also rejoined following his clash with Di Giannantonio, completing the finishers in 17th. Di Giannantonio himself re-entered the race, but had to retire due to a technical problem, while Bezzecchi did not see the finish following his crash.